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ybbA [2018-04-24 10:39:33]
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ybbA [2018-04-24 10:39:33]

enterobactin esterase, release of iron from enterobactin
locus
BSU01600
pI
7.91
mw
21.37 kDa
protein length
189 aa Sequence Blast
gene length
567 bp Sequence Blast
function
iron acquisition from enterobactin [pubmed|28283524]
product
enterobactin esterase [pubmed|28283524]
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]

    • Gene

    Coordinates
    179,595 → 180,347

    Expression and Regulation

    Operons

    genes
    [gene|516B13F337FD346B4A4A268E35D1EBABB05957E1|feuA]-[gene|57402D137E3D3791CAF0696421224F4E1DC1BA48|feuB]-[gene|F38F6D4841B3044EA0496B3A1C1D484018BDFEA4|feuC]-[gene|745167427618C4DA71848F9362043B66BC4E392E|ybbA]
    description
    [Pubmed|12354229]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|17725565], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]: repression, [pubmed|12354229], in [regulon|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur regulon]
  • [protein|EB28A65CECE994DF2DF486DEACF40F2533703DB0|Btr]: activation, in the presence of the co-activators bacillibactin or enterobactin [Pubmed|17725565], in [regulon|EB28A65CECE994DF2DF486DEACF40F2533703DB0|Btr regulon]

    • regulation

  • expression during spore [SW|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]
  • induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]) [pubmed|29133393]
  • expression of the operon is strongly induced at the beginning of [SW|biofilm formation] [pubmed|31113899]

    • additional information

  • the presence of an iron-responsive element bound by [SW|CitB] between ''[SW|feuA]'' and ''[SW|feuB]'' suggests iron-dependent regulation by [SW|CitB] [Pubmed|10468622]
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    Other regulations

  • [protein|E15E9F88B0E03FE8834C646369D2F4B4E713EF41|CitB]: translation control,

    • Biological materials

    Mutant

  • BKE01600 (Δ[gene|745167427618C4DA71848F9362043B66BC4E392E|ybbA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE01600 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTGTGTTCTGAAAGAGATC, downstream forward: _UP4_CGCTCAACCCTATGAGCGGT
  • BKK01600 (Δ[gene|745167427618C4DA71848F9362043B66BC4E392E|ybbA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK01600 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTGTGTTCTGAAAGAGATC, downstream forward: _UP4_CGCTCAACCCTATGAGCGGT

    • References

  • 17725565,12354229,10468622,27766092,28283524,29133393